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CNP SEMINAR : Dr Edwin Lim, PhD

Dans la série de CNP SEMINARS la prochaine conférence donnée par Dr Edwin Lim est intitulée "Involvement of tryptophan metabolism in psychiatric disorders: Focus on Autism and Schizophrenia"

Conférence | Salle Hirondelle, Site de Cery, 1008 Prilly | 15.11.2017 à 10h00
Publié par Viveka Sari

Centre de Neurosciences Psychiatriques

CNP SEMINAR ANNOUNCEMENT

Wednesday, November 15, 2017, 10:00, salle Hirondelle, site de Cery

“Involvement of tryptophan metabolism in psychiatric disorders: Focus on Autism and Schizophrenia”

 

Dr Edwin Lim, PhD

Department of Biomedical Sciences, Faculty of Medicine and Health Sciences,

Macquarie University, NSW 2109, Australia

Invited by Kim Do (Kim.Do@chuv.ch)

Abstract:

Dr Lim’s recent work published in New England Journal of Medicine revealed that NAD deficiency as a result of gene defects in the kynurenine pathway (KP) of the tryptophan metabolism may lead to multiple congenital malformation including vertebral segmentation, cardiac and renal defects. This talk will review several roles of the tryptophan metabolism involve in fetal development of the brain that can have immediate consequences (as outlined above) and also in later life with increased susceptibility to the development of psychiatric disorders.

Selected publications:

Shi H, Enriquez A, Rapadas M, Martin EMMA, Wang R, Moreau J, Lim CK, Szot JO, Hughes J, Sugimoto K, Humphreys D, McInerney-Leo AM, Leo PJ, Maghzal GJ, Halliday J, Smith J, Colley A, Mark PR, Collins F, Sillence DO, Winlaw DS, Ho J, Guillemin GJ, Brown MA, Kikuchi K, Thomas PQ, Stocker R, Giannoulatou E, Chapman G, Duncan EL, Sparrow DB, Dunwoodie SL. (2017) NAD deficiency, congenital malformations and niacin supplementation. N. Eng J. Med, 377:544-552

Lim CK*, Essa MM, de Paula Martins R, Lovejoy DB, Waly MI, Al-Farsi YM, Al-Sharbati M, Al-Shaffae MA, Guillemin GJ. (2015) Altered kynurenine pathway metabolism in autism: implication for enhanced glutamatergic activity through immune activation. Autism Research, 9(6): 621-31. *Corresponding author

Zavitsanou K, Lim CK, Purves-Tyson T, Karl T, Kassiou M, Banister SD, Guillemin GJ, Shannon-Weickert C. (2014) Effect of maternal immune activation on the kynurenine pathway in preadolescent rat offspring and on MK-801-induced hyperlocomotion in adulthood: amelioration by COX-2 inhibition. Brain, Behavior and Immunity, 41:173-181.

Erhardt S, Lim CK, Linderholm KR, Janelidze S, Lindqvist D, Samuelsson M, Lundberg K, Postolache TT, Träskman-Bendz L, Guillemin GJ, Brundin L. (2013) Connecting inflammation with glutamate agonism in suicidality. Neuropsychopharmacology, 38:743-752.



Document(s) annexe(s)

flyer Dr Edwin Lim
Directions to Salle Hirondelle (CERY) (CHUV)


Dernière mise à jour le 11.10.2017 17:43